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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520 Species: Mus musculus RGD Object: Gene Symbol: Cyp19a1 Name: cytochrome P450, family 19, subfamily a, polypeptide 1

Acc ID: CHEBI:17823 Term: calcitriol Definition: A hydroxycalciol that has formula C27H44O3. CasRN: 32222-06-3 Chemical ID: MESH:D002117

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1606587	6480464	CTD	Calcitriol promotes the reaction [Dexamethasone results in increased activity of CYP19A1 protein]	PMID:15862960
increases activity	ISO	RGD:1606587	6480464	CTD	Calcitriol results in increased activity of CYP19A1 protein	PMID:15862960
increases expression	ISO	RGD:1606587	6480464	CTD	Calcitriol results in increased expression of CYP19A1 mRNA	PMID:16002434