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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351456 Species: Homo sapiens RGD Object: Gene Symbol: FGF23 Name: fibroblast growth factor 23

Acc ID: CHEBI:17823 Term: calcitriol Definition: A hydroxycalciol that has formula C27H44O3. CasRN: 32222-06-3 Chemical ID: MESH:D002117

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects response to substance	EXP		6480464	CTD	FGF23 protein affects the susceptibility to Calcitriol	PMID:15698453
multiple interactions	ISO	RGD:734317	6480464	CTD	[Calcitriol co-treated with Phosphates] results in increased expression of FGF23 mRNA	PMID:15671080
increases expression	EXP		6480464	CTD	Calcitriol results in increased expression of FGF23 protein	PMID:16234967 PMID:18256372 PMID:15956805
increases expression	ISO	RGD:734317	6480464	CTD	Calcitriol results in increased expression of FGF23 mRNA Calcitriol results in increased expression of FGF23 protein	PMID:16020653
decreases abundance	EXP		6480464	CTD	FGF23 protein results in decreased abundance of Calcitriol	PMID:15917335 PMID:15264182
multiple interactions	ISO	RGD:734317	6480464	CTD	PHEX protein inhibits the reaction [FGF23 protein results in decreased abundance of Calcitriol]	PMID:16449303
increases expression	ISO	RGD:620178	6480464	CTD	Calcitriol results in increased expression of FGF23 mRNA	PMID:16020653
increases expression	ISO	RGD:620178	6480464	CTD	Calcitriol results in increased expression of FGF23 mRNA	PMID:17293108
increases expression	ISO	RGD:620178	6480464	CTD	Calcitriol results in increased expression of FGF23 protein	PMID:15531762
decreases abundance	EXP		6480464	CTD	FGF23 protein results in decreased abundance of Calcitriol	PMID:15264182 PMID:15917335
increases expression	EXP		6480464	CTD	Calcitriol results in increased expression of FGF23 protein	PMID:18256372 PMID:16234967 PMID:15956805
increases expression	EXP		6480464	CTD	Calcitriol results in increased expression of FGF23 protein	PMID:16234967 PMID:15956805 PMID:18256372
increases expression	EXP		6480464	CTD	Calcitriol results in increased expression of FGF23 protein	PMID:15956805 PMID:18256372 PMID:16234967
increases expression	EXP		6480464	CTD	Calcitriol results in increased expression of FGF23 protein	PMID:15956805 PMID:16234967 PMID:18256372