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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620795
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srcdecreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of SRC proteinPMID:30565266
Srcmultiple interactionsEXP 6480464CTD[INS1 protein co-treated with Diethylhexyl Phthalate] results in decreased expression of SRC proteinPMID:28526321
Srcdecreases expressionISOSRC (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of SRC proteinPMID:31163220
Srcdecreases phosphorylationISOSrc (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased phosphorylation of SRC proteinPMID:35259346
Srcmultiple interactionsISOSrc (Mus musculus)6480464CTDicariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of SRC protein]PMID:35259346
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