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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620298
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg5
Name: ATP binding cassette subfamily G member 5
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg5decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of ABCG5 mRNA; Diethylhexyl Phthalate results in decreased expression of ABCG5 proteinPMID:35970509
Abcg5multiple interactionsISOAbcg5 (Mus musculus)6480464CTD[APOE gene mutant form results in increased susceptibility to Diethylhexyl Phthalate] which results in decreased expression of ABCG5 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of ABCG5 mRNAPMID:25270622 PMID:35739755
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