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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621812
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3decreases expressionISOCxcl3 (Mus musculus)6480464CTDNicotine results in decreased expression of CXCL1 mRNAPMID:22093924
Cxcl3decreases secretionISOCxcl3 (Mus musculus)6480464CTDNicotine results in decreased secretion of CXCL1 proteinPMID:22093924
Cxcl3increases expressionISOCxcl3 (Mus musculus)6480464CTDNicotine results in increased expression of CXCL1 proteinPMID:16254210
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