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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaaffects response to substanceEXP 6480464CTDNicotine affects the susceptibility to VEGFAPMID:21378373
Vegfadecreases expressionEXP 6480464CTDNicotine results in decreased expression of VEGFA proteinPMID:33091441
Vegfaincreases expressionEXP 6480464CTDNicotine results in increased expression of VEGFA mRNA; Nicotine results in increased expression of VEGFA proteinPMID:16499655 PMID:20426880
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDNicotine results in decreased secretion of VEGFA proteinPMID:23618901
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDNicotine results in increased expression of VEGFA mRNA; Nicotine results in increased expression of VEGFA proteinPMID:14569062 PMID:20457658 PMID:24793809 PMID:26536586 PMID:27552315 PMID:30836163
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDNicotine results in increased expression of VEGFA mRNAPMID:32512034
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDNicotine results in increased secretion of VEGFA proteinPMID:22198237
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDCHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]PMID:24793809 PMID:30836163
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNAPMID:33091441
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