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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases expressionEXP 6480464CTDNicotine results in increased expression of CASP9 proteinPMID:29972271
Casp9multiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Nicotine results in increased expression of CASP9 protein]PMID:29972271
Casp9decreases expressionISOCASP9 (Homo sapiens)6480464CTDNicotine results in decreased expression of CASP9 mRNAPMID:16949557
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CASP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]PMID:20230807
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDNicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]PMID:18676776
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