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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736793 Species: Homo sapiens RGD Object: Gene Symbol: GCLC Name: glutamate-cysteine ligase, catalytic subunit

Acc ID: CHEBI:17650 Term: cortisol Definition: Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses CasRN: 50-23-7 Chemical ID: MESH:D006854

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:619868	6480464	CTD	Hydrocortisone results in increased expression of GCLC mRNA	PMID:10978506