GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i2 | decreases activity | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | Glucose results in decreased activity of NR1I2 protein | PMID:21682256 | Nr1i2 | decreases expression | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of NR1I2 mRNA | PMID:22363694 | Nr1i2 | increases expression | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of NR1I2 mRNA | PMID:36156098 | Nr1i2 | multiple interactions | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | [Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose; Ketoconazole inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose; Polyphenols inhibits the reaction [Glucose results in decreased activity of NR1I2 protein]; resveratrol inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; SGK2 mutant form inhibits the reaction [[Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose] | PMID:21682256 PMID:24204015 PMID:26616219 | | ||||||||||||||||||||||
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