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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732 Species: Rattus norvegicus RGD Object: Gene Symbol: Sod2 Name: superoxide dismutase 2, mitochondrial

Acc ID: CHEBI:17634 Term: D-glucose Definition: null CasRN: 50-99-7 Chemical ID: MESH:D005947

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730872	6480464	CTD	Acetylcysteine inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein] CAT inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]	PMID:17309078
affects folding	ISO	RGD:730872	6480464	CTD	Glucose deficiency affects the folding of SOD2 protein	PMID:17309078
decreases expression	ISO	RGD:11330	6480464	CTD	Glucose results in decreased expression of SOD2 protein	PMID:18483403
multiple interactions	ISO	RGD:11330	6480464	CTD	pimagedine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]	PMID:18483403
decreases expression	EXP		6480464	CTD	Glucose results in decreased expression of SOD2 mRNA	PMID:21818840
multiple interactions	ISO	RGD:11330	6480464	CTD	[Glucose co-treated with SOD2 gene mutant form] results in decreased expression of HIF1A protein	PMID:19429140
decreases expression	ISO	RGD:730872	6480464	CTD	Glucose deficiency results in decreased expression of SOD2 protein	PMID:22314686
multiple interactions	ISO	RGD:730872	6480464	CTD	SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein] SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] SOD2 protein inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA] SOD2 protein inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA] SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	PMID:11050244
decreases response to substance	ISO	RGD:730872	6480464	CTD	SOD2 protein results in decreased susceptibility to Glucose	PMID:11050244
multiple interactions	ISO	RGD:730872	6480464	CTD	SOD2 protein inhibits the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] SOD2 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone]	PMID:14514642
multiple interactions	ISO	RGD:11330	6480464	CTD	resveratrol inhibits the reaction [Glucose results in decreased expression of SOD2 protein]	PMID:23090186
increases expression	ISO	RGD:11330	6480464	CTD	Glucose results in increased expression of SOD2 protein	PMID:23090186