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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases expressionEXP 6480464CTDGlucose results in decreased expression of SOD2 mRNA; Glucose results in decreased expression of SOD2 proteinPMID:21818840 PMID:22413817 PMID:23159718 PMID:23192364 PMID:25162824 PMID:28027979 PMID:31639451
Sod2increases expressionEXP 6480464CTDGlucose results in increased expression of SOD2 mRNAPMID:24349266
Sod2multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; KU-32 compound inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; naringenin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; SRT1720 inhibits the reaction [Glucose results in decreased expression of SOD2 protein]PMID:22413817 PMID:23159718 PMID:23192364 PMID:25162824 PMID:31639451
Sod2affects expressionISOSOD2 (Homo sapiens)6480464CTDGlucose affects the expression of SOD2 mRNAPMID:32942007
Sod2affects foldingISOSOD2 (Homo sapiens)6480464CTDGlucose deficiency affects the folding of SOD2 proteinPMID:17309078
Sod2decreases activityISOSOD2 (Homo sapiens)6480464CTDGlucose results in decreased activity of SOD2 proteinPMID:23329836
Sod2decreases expressionISOSod2 (Mus musculus)6480464CTDGlucose results in decreased expression of SOD2 proteinPMID:18483403
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTDGlucose deficiency results in decreased expression of SOD2 proteinPMID:22314686
Sod2decreases response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein results in decreased susceptibility to GlucosePMID:11050244
Sod2decreases secretionISOSOD2 (Homo sapiens)6480464CTDGlucose deficiency results in decreased secretion of SOD2 proteinPMID:24802182
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDGlucose results in increased expression of SOD2 proteinPMID:23090186
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDGlucose deficiency results in increased expression of SOD2 protein; Glucose results in increased expression of SOD2 proteinPMID:23494737
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTD[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] results in decreased expression of SOD2 protein; [Glucose co-treated with SOD2 gene mutant form] results in decreased expression of HIF1A protein; IL6 protein inhibits the reaction [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] results in decreased expression of SOD2 protein]; pimagedine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; resveratrol inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; SOD2 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]PMID:18483403 PMID:19429140 PMID:21940958 PMID:23090186 PMID:25979314
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD2,3-bis(4-hydroxyphenyl)-propionitrile inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in decreased expression of SOD2 protein]]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of SOD2 protein]; Acetylcysteine inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]; CAT inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]; Fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of SOD2 protein]]; Glucose results in decreased expression of and results in decreased activity of SOD2 protein; manganese chloride inhibits the reaction [Glucose results in decreased activity of SOD2 protein]; SIRT3 protein inhibits the reaction [Glucose results in increased expression of SOD2 protein]; SOD2 inhibits the reaction [Glucose results in decreased expression of GLO1 protein]; SOD2 inhibits the reaction [Glucose results in increased expression of AGER mRNA]; SOD2 inhibits the reaction [Glucose results in increased expression of AGER protein]; SOD2 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]; SOD2 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]; SOD2 inhibits the reaction [Glucose results in increased expression of S100A12 mRNA]; SOD2 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]; SOD2 inhibits the reaction [Glucose results in increased expression of S100A8 protein]; SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]; SOD2 protein inhibits the reaction [Glucose results in decreased activity of and results in increased ADP-ribosylation of GAPDH protein]; SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]; SOD2 protein inhibits the reaction [Glucose results in increased activity of PARP1 protein]; SOD2 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone]; SOD2 protein inhibits the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]; SOD2 protein inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]; SOD2 protein inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]PMID:11050244 PMID:14514642 PMID:14523042 PMID:17309078 PMID:19833897 PMID:20962025 PMID:23329836 PMID:23494737
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