GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp1 | increases activity | EXP | | 6480464 | CTD | Glucose results in increased activity of CASP1 mRNA; Glucose results in increased activity of CASP1 protein | PMID:21832250 | Casp1 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of CASP1 protein | PMID:23647015 PMID:29031534 | Casp1 | multiple interactions | EXP | | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP1 protein modified form; Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP1 protein modified form]; L 709049 analog inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of CASP1 protein]; rhodioloside inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Suramin inhibits the reaction [Glucose results in increased activity of CASP1 protein]; TXNIP mRNA promotes the reaction [Glucose results in increased expression of CASP1 protein] | PMID:21832250 PMID:23647015 PMID:29031534 PMID:35191607 | Casp1 | increases cleavage | ISO | Casp1 (Mus musculus) | 6480464 | CTD | Glucose results in increased cleavage of CASP1 protein | PMID:27783111 | Casp1 | increases cleavage | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Glucose results in increased cleavage of CASP1 protein | PMID:35607288 | Casp1 | increases expression | ISO | Casp1 (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of CASP1 mRNA | PMID:34212273 | Casp1 | increases expression | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of CASP1 mRNA; Glucose results in increased expression of CASP1 protein | PMID:23647015 PMID:36066211 PMID:37473909 | Casp1 | multiple interactions | ISO | Casp1 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Glucose results in increased cleavage of CASP1 protein]; FOXO3 protein promotes the reaction [Glucose results in increased cleavage of and results in increased activity of CASP1 protein]; Glucose results in increased cleavage of and results in increased activity of CASP1 protein; Glucose results in increased expression of and results in increased cleavage of CASP1 protein | PMID:20370652 PMID:27783111 PMID:34212273 | Casp1 | multiple interactions | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | [Glucose co-treated with TGFB1 protein] results in increased cleavage of CASP1 protein; Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]; aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased cleavage of CASP1 protein]; L 709049 analog inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Lipopolysaccharides inhibits the reaction [swietenine inhibits the reaction [Glucose results in increased expression of CASP1 protein]]; Lipopolysaccharides promotes the reaction [Glucose results in increased expression of CASP1 protein]; loganin inhibits the reaction [Glucose results in increased expression of CASP1 mRNA]; loganin inhibits the reaction [Glucose results in increased expression of CASP1 protein]; MIR200C mRNA affects the reaction [Glucose results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Glucose results in increased expression of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [swietenine inhibits the reaction [Glucose results in increased expression of CASP1 protein]]; Quercetin inhibits the reaction [Glucose results in increased expression of CASP1 protein]; SLC30A7 protein affects the reaction [MIR200C mRNA affects the reaction [Glucose results in increased cleavage of CASP1 protein]]; swietenine inhibits the reaction [Glucose results in increased expression of CASP1 protein]; TXNIP mRNA promotes the reaction [Glucose results in increased expression of CASP1 protein] | PMID:23647015 PMID:35607288 PMID:35961541 PMID:36066211 PMID:37473909 | |
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