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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases activityEXP 6480464CTDGlucose results in increased activity of CASP1 mRNA; Glucose results in increased activity of CASP1 proteinPMID:21832250
Casp1increases expressionEXP 6480464CTDGlucose results in increased expression of CASP1 proteinPMID:23647015 PMID:29031534
Casp1multiple interactionsEXP 6480464CTD[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP1 protein modified form; Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP1 protein modified form]; L 709049 analog inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of CASP1 protein]; rhodioloside inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Suramin inhibits the reaction [Glucose results in increased activity of CASP1 protein]; TXNIP mRNA promotes the reaction [Glucose results in increased expression of CASP1 protein]PMID:21832250 PMID:23647015 PMID:29031534 PMID:35191607
Casp1increases cleavageISOCasp1 (Mus musculus)6480464CTDGlucose results in increased cleavage of CASP1 proteinPMID:27783111
Casp1increases cleavageISOCASP1 (Homo sapiens)6480464CTDGlucose results in increased cleavage of CASP1 proteinPMID:35607288
Casp1increases expressionISOCasp1 (Mus musculus)6480464CTDGlucose results in increased expression of CASP1 mRNAPMID:34212273
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDGlucose results in increased expression of CASP1 mRNA; Glucose results in increased expression of CASP1 proteinPMID:23647015 PMID:36066211 PMID:37473909
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Glucose results in increased cleavage of CASP1 protein]; FOXO3 protein promotes the reaction [Glucose results in increased cleavage of and results in increased activity of CASP1 protein]; Glucose results in increased cleavage of and results in increased activity of CASP1 protein; Glucose results in increased expression of and results in increased cleavage of CASP1 proteinPMID:20370652 PMID:27783111 PMID:34212273
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTD[Glucose co-treated with TGFB1 protein] results in increased cleavage of CASP1 protein; Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]; aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased cleavage of CASP1 protein]; L 709049 analog inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Lipopolysaccharides inhibits the reaction [swietenine inhibits the reaction [Glucose results in increased expression of CASP1 protein]]; Lipopolysaccharides promotes the reaction [Glucose results in increased expression of CASP1 protein]; loganin inhibits the reaction [Glucose results in increased expression of CASP1 mRNA]; loganin inhibits the reaction [Glucose results in increased expression of CASP1 protein]; MIR200C mRNA affects the reaction [Glucose results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Glucose results in increased expression of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [swietenine inhibits the reaction [Glucose results in increased expression of CASP1 protein]]; Quercetin inhibits the reaction [Glucose results in increased expression of CASP1 protein]; SLC30A7 protein affects the reaction [MIR200C mRNA affects the reaction [Glucose results in increased cleavage of CASP1 protein]]; swietenine inhibits the reaction [Glucose results in increased expression of CASP1 protein]; TXNIP mRNA promotes the reaction [Glucose results in increased expression of CASP1 protein]PMID:23647015 PMID:35607288 PMID:35961541 PMID:36066211 PMID:37473909
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