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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:17620
Term: ferulic acid
Definition: A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring.
Chemical ID: MESH:C004999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases activityEXP 6480464CTDferulic acid results in decreased activity of MAPK1 proteinPMID:15363954
Mapk1multiple interactionsEXP 6480464CTD[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK1 proteinPMID:21203465
Mapk1decreases activityISOMAPK1 (Homo sapiens)6480464CTDferulic acid results in decreased activity of MAPK1 proteinPMID:15486966
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