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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3010
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lipe
Name: lipase E, hormone sensitive type
Acc ID: CHEBI:17616
Term: all-trans-retinyl palmitate
Definition: An all-trans-retinyl ester obtained by formal condensation of the carboxy group of palmitic (hexadecanoic acid) with the hydroxy group of all-trans-retinol. It is used in cosmetic products to treat various skin disorders such as acne, skin aging, wrinkles, dark spots, and also protect against psoriasis.
Chemical ID: MESH:C014794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lipeincreases hydrolysisISOLIPE (Homo sapiens)6480464CTDLIPE protein results in increased hydrolysis of retinol palmitatePMID:16741517
Lipemultiple interactionsISOLIPE (Homo sapiens)6480464CTDPLIN3 protein inhibits the reaction [LIPE protein results in increased hydrolysis of retinol palmitate]PMID:16741517
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