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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDhydroquinone results in increased expression of MMP9 mRNA; hydroquinone results in increased expression of MMP9 proteinPMID:26807887 PMID:27515134 PMID:33771647 PMID:33932074
Mmp9increases secretionISOMMP9 (Homo sapiens)6480464CTDhydroquinone results in increased secretion of MMP9 proteinPMID:26807887
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDCDKN2A protein affects the reaction [hydroquinone results in increased expression of MMP9 mRNA]; CDKN2A protein affects the reaction [hydroquinone results in increased expression of MMP9 protein]; hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]]; hydroquinone promotes the reaction [TNF protein results in increased secretion of MMP9 protein]; PARP1 protein affects the reaction [hydroquinone results in increased expression of MMP9 mRNA]; PARP1 protein inhibits the reaction [hydroquinone results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [hydroquinone results in increased secretion of MMP9 protein]; SB 203580 inhibits the reaction [hydroquinone results in increased secretion of MMP9 protein]PMID:17669387 PMID:26807887 PMID:33771647 PMID:33932074
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