GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Wrn | decreases response to substance | ISO | WRN (Homo sapiens) | 6480464 | CTD | WRN protein results in decreased susceptibility to hydroquinone | PMID:17875398 PMID:18978339 PMID:19064679 | Wrn | increases response to substance | ISO | WRN (Homo sapiens) | 6480464 | CTD | WRN gene mutant form results in increased susceptibility to hydroquinone | PMID:21267443 | Wrn | multiple interactions | ISO | WRN (Homo sapiens) | 6480464 | CTD | WRN gene mutant form promotes the reaction [hydroquinone results in increased expression of H2AX protein alternative form]; WRN protein affects the reaction [hydroquinone results in increased acetylation of TP53 protein]; WRN protein affects the reaction [hydroquinone results in increased expression of H2AX protein]; WRN protein affects the reaction [hydroquinone results in increased expression of TP53 protein]; WRN protein inhibits the reaction [hydroquinone results in increased cleavage of CASP7 protein]; WRN protein inhibits the reaction [hydroquinone results in increased cleavage of PARP1 protein] | PMID:17875398 PMID:19064679 PMID:21267443 | |
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