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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564788
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wrn
Name: WRN RecQ like helicase
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wrndecreases response to substanceISOWRN (Homo sapiens)6480464CTDWRN protein results in decreased susceptibility to hydroquinonePMID:17875398 PMID:18978339 PMID:19064679
Wrnincreases response to substanceISOWRN (Homo sapiens)6480464CTDWRN gene mutant form results in increased susceptibility to hydroquinonePMID:21267443
Wrnmultiple interactionsISOWRN (Homo sapiens)6480464CTDWRN gene mutant form promotes the reaction [hydroquinone results in increased expression of H2AX protein alternative form]; WRN protein affects the reaction [hydroquinone results in increased acetylation of TP53 protein]; WRN protein affects the reaction [hydroquinone results in increased expression of H2AX protein]; WRN protein affects the reaction [hydroquinone results in increased expression of TP53 protein]; WRN protein inhibits the reaction [hydroquinone results in increased cleavage of CASP7 protein]; WRN protein inhibits the reaction [hydroquinone results in increased cleavage of PARP1 protein]PMID:17875398 PMID:19064679 PMID:21267443
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