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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620795
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Acc ID: CHEBI:175901
Term: gemcitabine
Definition: A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
Chemical ID: MESH:C056507
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srcaffects response to substanceISOSRC (Homo sapiens)6480464CTDSRC protein affects the susceptibility to GemcitabinePMID:15073106
Srcdecreases response to substanceISOSRC (Homo sapiens)6480464CTDSRC protein modified form results in decreased susceptibility to Gemcitabine; SRC protein results in decreased susceptibility to GemcitabinePMID:15073106 PMID:15194078
Srcmultiple interactionsISOSRC (Homo sapiens)6480464CTD[AG 1879 co-treated with SRC] results in increased susceptibility to GemcitabinePMID:15073106
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