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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:175901
Term: gemcitabine
Definition: A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
Chemical ID: MESH:C056507
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDGemcitabine results in increased activity of CASP9 proteinPMID:12479703 PMID:15476743 PMID:17159604 PMID:26050647
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDGemcitabine results in increased cleavage of CASP9 proteinPMID:15726400
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTD[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 proteinPMID:17440100
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[Calcitriol co-treated with Gemcitabine] results in increased expression of CASP9 protein; Quercetin promotes the reaction [Gemcitabine results in increased activity of CASP9 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP9 protein]PMID:20699664 PMID:21418860 PMID:26050647
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