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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:17356
Term: 2-acetamidofluorene
Definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Chemical ID: MESH:D015073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases expressionEXP 6480464CTD2-Acetylaminofluorene results in increased expression of NR1I2 mRNAPMID:16381673
Nr1i2multiple interactionsEXP 6480464CTDNR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]PMID:12504080
Nr1i2increases expressionISONR1I2 (Homo sapiens)6480464CTD2-Acetylaminofluorene results in increased expression of NR1I2 mRNAPMID:16381673
Nr1i2increases expressionISONr1i2 (Mus musculus)6480464CTD2-Acetylaminofluorene results in increased expression of NR1I2 mRNAPMID:16381673
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDNR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A11 mRNA]PMID:16381673
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