GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a9 | affects metabolic processing | EXP | | 6480464 | CTD | CYP3A9 protein affects the metabolism of Testosterone | PMID:15879494 | Cyp3a9 | multiple interactions | EXP | | 6480464 | CTD | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CYP3A9 mRNA | PMID:32741896 | Cyp3a9 | decreases expression | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | Testosterone results in decreased expression of CYP3A5 mRNA | PMID:33359661 | Cyp3a9 | increases expression | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | Testosterone results in increased expression of CYP3A5 mRNA | PMID:21592394 | Cyp3a9 | increases hydroxylation | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | CYP3A5 protein results in increased hydroxylation of Testosterone | PMID:15383492 PMID:15499178 PMID:15845858 PMID:15876487 PMID:16012074 PMID:26239802 PMID:26763401 PMID:31102695 PMID:34189909 | Cyp3a9 | multiple interactions | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | [CYP3A5 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone; [Testosterone co-treated with Calcitriol] results in increased expression of CYP3A5 mRNA; alpha-Tocopherol inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; CYP3A5 gene polymorphism affects the reaction [CYP3A5 gene results in increased hydroxylation of Testosterone]; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; erdafitinib inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Meclizine inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; plastochromanol 8 inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Sulfaphenazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Testosterone inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Tocotrienols inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone] | PMID:21592394 PMID:26239802 PMID:31102695 PMID:34189909 | | ||||||||||||||||||||||
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