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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1increases expressionEXP 6480464CTDTestosterone results in increased expression of IGF1 mRNA; Testosterone results in increased expression of IGF1 proteinPMID:10100480 PMID:15917159 PMID:26492952 PMID:29247772
Igf1multiple interactionsEXP 6480464CTDchrysin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]PMID:26492952 PMID:29247772
Igf1affects expressionISOIgf1 (Mus musculus)6480464CTDTestosterone affects the expression of IGF1 mRNAPMID:20403060
Igf1decreases expressionISOIgf1 (Mus musculus)6480464CTDTestosterone deficiency results in decreased expression of IGF1 mRNA; Testosterone results in decreased expression of IGF1 mRNAPMID:21045173 PMID:22138414
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDTestosterone results in increased expression of IGF1 mRNA; Testosterone results in increased expression of IGF1 proteinPMID:16002536 PMID:16368782
Igf1increases secretionISOIGF1 (Homo sapiens)6480464CTDTestosterone results in increased secretion of IGF1 proteinPMID:16368782
Igf1multiple interactionsISOIgf1 (Mus musculus)6480464CTDTestosterone inhibits the reaction [Testosterone deficiency results in decreased expression of IGF1 mRNA]PMID:21045173
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