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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1affects expressionEXP 6480464CTDTestosterone affects the expression of EDN1 mRNAPMID:12122504 PMID:14616470
Edn1increases expressionISOEdn1 (Mus musculus)6480464CTDTestosterone deficiency results in increased expression of EDN1 mRNAPMID:33848595
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDTestosterone results in increased expression of EDN1 mRNAPMID:21592394
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of EDN1 mRNAPMID:21592394
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