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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2multiple interactionsEXP 6480464CTDTestosterone inhibits the reaction [Dexamethasone results in increased expression of ABCC2 mRNA]PMID:20032058
Abcc2increases expressionISOAbcc2 (Mus musculus)6480464CTDTestosterone deficiency results in increased expression of ABCC2 mRNAPMID:22522787
Abcc2multiple interactionsISOAbcc2 (Mus musculus)6480464CTD[ABCC1 gene mutant form results in increased susceptibility to Testosterone deficiency] which results in increased expression of ABCC2 mRNA; ABCC1 gene mutant form inhibits the reaction [Testosterone deficiency results in increased expression of ABCC2 mRNA]PMID:22522787
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