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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553569 Species: Mus musculus RGD Object: Gene Symbol: Nr3c2 Name: nuclear receptor subfamily 3, group C, member 2

Acc ID: CHEBI:17347 Term: testosterone Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5. CasRN: 58-22-0 Chemical ID: MESH:D013739

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects binding	ISO	RGD:733363	6480464	CTD	Testosterone binds to NR3C2 protein	PMID:17105867
multiple interactions	ISO	RGD:733363	6480464	CTD	Testosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]	PMID:17105867