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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10388 Species: Mus musculus RGD Object: Gene Symbol: Cpd Name: carboxypeptidase D

Acc ID: CHEBI:17347 Term: testosterone Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5. CasRN: 58-22-0 Chemical ID: MESH:D013739

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731463	6480464	CTD	SRD5A1 promotes the reaction [Testosterone results in increased expression of CPD mRNA] [Testosterone results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide	PMID:21688280
increases expression	ISO	RGD:731463	6480464	CTD	Testosterone results in increased expression of CPD mRNA Testosterone results in increased expression of CPD protein	PMID:21688280
multiple interactions	ISO	RGD:2393	6480464	CTD	[Estradiol co-treated with Testosterone] results in increased expression of CPD mRNA	PMID:11375906