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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733197
Species: Homo sapiens
RGD Object: Gene
Symbol: TRPV1
Name: transient receptor potential cation channel subfamily V member 1
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TRPV1affects activityISOTrpv1 (Mus musculus)6480464CTDMorphine affects the activity of TRPV1 proteinPMID:22189556
TRPV1affects response to substanceISOTrpv1 (Mus musculus)6480464CTDTRPV1 protein affects the susceptibility to MorphinePMID:18774343
TRPV1increases expressionISOTrpv1 (Rattus norvegicus)6480464CTDMorphine results in increased expression of TRPV1; Morphine results in increased expression of TRPV1 proteinPMID:18774343 PMID:20719804
TRPV1multiple interactionsISOTrpv1 (Mus musculus)6480464CTD[N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide binds to and results in decreased activity of TRPV1 protein] which results in decreased susceptibility to MorphinePMID:18774343
TRPV1multiple interactionsISOTrpv1 (Rattus norvegicus)6480464CTD[N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide binds to and results in decreased activity of TRPV1 protein] which results in decreased susceptibility to MorphinePMID:18774343
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