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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619831 Species: Rattus norvegicus RGD Object: Gene Symbol: Fas Name: Fas (TNF receptor superfamily, member 6)

Acc ID: CHEBI:17303 Term: morphine Definition: A highly potent opiate analgesic psychoactive drug, morphine acts directly on the central nervous system (CNS) to relieve pain. Morphine has a high potential for addiction; tolerance and both physical and psychological dependence develop rapidly. CasRN: 57-27-2 Chemical ID: MESH:D009020

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1552455	6480464	CTD	[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]	PMID:16210602
increases expression	ISO	RGD:1552455	6480464	CTD	Morphine results in increased expression of FAS mRNA	PMID:16210602
multiple interactions	ISO	RGD:1346266	6480464	CTD	[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein	PMID:12702572