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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adora1
Name: adenosine A1 receptor
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adora1increases expressionEXP 6480464CTDMorphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 proteinPMID:26478469
Adora1multiple interactionsEXP 6480464CTD[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 proteinPMID:26478469
Adora1affects response to substanceISOAdora1 (Mus musculus)6480464CTDADORA1 protein affects the susceptibility to MorphinePMID:9407998
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