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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2835 Species: Rattus norvegicus RGD Object: Gene Symbol: Hsd11b2 Name: hydroxysteroid 11-beta dehydrogenase 2

Acc ID: CHEBI:17243 Term: mono(2-ethylhexyl) phthalate Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid. CasRN: 4376-20-9 Chemical ID: MESH:C016599

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:737468	6480464	CTD	mono-(2-ethylhexyl)phthalate results in decreased activity of HSD11B2 protein	PMID:19786001
decreases activity	EXP		6480464	CTD	mono-(2-ethylhexyl)phthalate results in decreased activity of HSD11B2 protein	PMID:19786001
affects expression	ISO	RGD:10735	6480464	CTD	mono-(2-ethylhexyl)phthalate affects the expression of HSD11B2 mRNA	PMID:21195148