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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs2
Name: insulin receptor substrate 2
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irs2decreases expressionISOIRS2 (Homo sapiens)6480464CTDGlucose results in decreased expression of IRS2 protein; Glucose results in decreased expression of IRS2 protein modified formPMID:24262486
Irs2increases abundanceISOIrs2 (Mus musculus)6480464CTDIRS2 gene mutant form results in increased abundance of GlucosePMID:20028942
Irs2increases phosphorylationISOIRS2 (Homo sapiens)6480464CTDGlucose results in increased phosphorylation of IRS2 proteinPMID:10430617
Irs2multiple interactionsISOIRS2 (Homo sapiens)6480464CTDCatechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form]; Catechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein]; Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form]; Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS2 protein]PMID:24262486
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