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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69316 Species: Rattus norvegicus RGD Object: Gene Symbol: Irs2 Name: insulin receptor substrate 2

Acc ID: CHEBI:17234 Term: glucose Definition: null CasRN: 50-99-7 Chemical ID: MESH:D005947

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases phosphorylation	ISO	RGD:736204	6480464	CTD	Glucose results in increased phosphorylation of IRS2 protein	PMID:10430617
increases abundance	ISO	RGD:736205	6480464	CTD	IRS2 gene mutant form results in increased abundance of Glucose	PMID:20028942