GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vegfa | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of VEGFA mRNA | PMID:19609456 | Vegfa | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of VEGFA mRNA; Glucose results in increased expression of VEGFA protein | PMID:18569938 PMID:19759273 PMID:26891083 | Vegfa | multiple interactions | EXP | | 6480464 | CTD | [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of VEGFA protein]; HIF1A protein affects the reaction [Glucose results in increased expression of VEGFA protein]; manumycin inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; MIR217 mRNA affects the reaction [Glucose results in increased expression of VEGFA protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]; Rosiglitazone inhibits the reaction [Glucose results in decreased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]] | PMID:18569938 PMID:19609456 PMID:22467055 PMID:26891083 | Vegfa | decreases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of VEGFA mRNA | PMID:31655124 | Vegfa | increases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Glucose deficiency results in increased expression of VEGFA mRNA; Glucose results in increased expression of VEGFA mRNA; Glucose results in increased expression of VEGFA protein | PMID:12147617 PMID:20578705 PMID:33962019 PMID:35264022 | Vegfa | increases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of VEGFA protein | PMID:21617913 | Vegfa | increases secretion | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Glucose deficiency results in increased secretion of VEGFA protein | PMID:12147617 | Vegfa | multiple interactions | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | [cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA; [cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein; [Glucose co-treated with Deferoxamine] results in increased expression of VEGFA mRNA; [Glucose co-treated with Resveratrol] results in decreased expression of VEGFA mRNA; Fluorometholone inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; Fluorometholone inhibits the reaction [Glucose results in increased expression of VEGFA protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of VEGFA mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein] | PMID:20578705 PMID:24064760 PMID:25192544 PMID:33962019 PMID:35264022 | Vegfa | multiple interactions | ISO | Vegfa (Mus musculus) | 6480464 | CTD | 2-methoxyestradiol inhibits the reaction [Glucose results in increased expression of VEGFA protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Glucose results in increased expression of VEGFA protein]; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of VEGFA protein | PMID:19228841 PMID:21617913 | | ||||||||||||||||||||||
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