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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2711
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a4
Name: solute carrier family 2 member 4
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a4decreases expressionEXP 6480464CTDGlucose results in decreased expression of SLC2A4 mRNAPMID:1727734
Slc2a4increases expressionEXP 6480464CTDGlucose results in increased expression of SLC2A4 mRNAPMID:15111496
Slc2a4multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose]; [[Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Resveratrol results in increased localization of SLC2A4 protein] which results in increased uptake of Glucose; ESR1 protein promotes the reaction [[Resveratrol results in increased localization of SLC2A4 protein] which results in increased uptake of Glucose]; Fulvestrant inhibits the reaction [[Resveratrol results in increased localization of SLC2A4 protein] which results in increased uptake of Glucose]PMID:18426865 PMID:27160165
Slc2a4decreases expressionISOSLC2A4 (Homo sapiens)6480464CTDGlucose results in decreased expression of SLC2A4 proteinPMID:33957017
Slc2a4increases uptakeISOSlc2a4 (Mus musculus)6480464CTDSLC2A4 protein results in increased uptake of GlucosePMID:19373748 PMID:19477051
Slc2a4multiple interactionsISOSLC2A4 (Homo sapiens)6480464CTDACACB protein affects the reaction [Glucose results in decreased expression of SLC2A4 protein]PMID:33957017
Slc2a4multiple interactionsISOSlc2a4 (Mus musculus)6480464CTD[3,3',4,5'-tetrahydroxystilbene results in increased localization of SLC2A4 protein] which results in increased uptake of Glucose; [Glucose co-treated with picolinic acid] affects the localization of SLC2A4 protein; Glucosamine inhibits the reaction [SLC2A4 protein results in increased uptake of Glucose]; Glucose inhibits the reaction [SLC2A4 protein results in increased uptake of Glucosamine]; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Glucose]; MYH2 protein affects the reaction [SLC2A4 protein results in increased uptake of Glucose]; Plant Extracts promotes the reaction [SLC2A4 protein results in increased uptake of Glucose]PMID:16870493 PMID:18773891 PMID:19373748 PMID:19477051 PMID:22579688
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