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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1affects expressionEXP 6480464CTDGlucose affects the expression of SIRT1 proteinPMID:24349266
Sirt1decreases expressionEXP 6480464CTDGlucose results in decreased expression of SIRT1 mRNA; Glucose results in decreased expression of SIRT1 proteinPMID:22561310 PMID:25162824 PMID:26891083 PMID:31639451 PMID:35243728
Sirt1increases response to substanceEXP 6480464CTDSIRT1 protein results in increased susceptibility to GlucosePMID:16366736
Sirt1multiple interactionsEXP 6480464CTD[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]; [SRT1720 results in increased activity of SIRT1 protein] which results in increased abundance of Glucose; Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; Inositol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; MIR217 mRNA affects the reaction [Glucose results in decreased expression of SIRT1 mRNA]; MIR217 mRNA affects the reaction [Glucose results in decreased expression of SIRT1 protein]; NAD inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; Sirolimus inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of CCN2 protein]]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein]]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A protein]]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of TGFB1 protein]]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]]; SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein]; SIRT1 protein promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]; SIRT1 protein promotes the reaction [Glucose results in increased expression of INS1 protein]; SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]; SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of GLB1 protein]]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of GLB1 protein]]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of GLB1 protein]]; SRT1720 inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; UCP2 protein inhibits the reaction [SIRT1 protein promotes the reaction [Glucose results in increased expression of INS1 protein]]PMID:16366736 PMID:21212096 PMID:22561310 PMID:25162824 PMID:26891083 PMID:31639451 PMID:35243728
Sirt1affects abundanceISOSirt1 (Mus musculus)6480464CTDSIRT1 protein affects the abundance of GlucosePMID:18849969
Sirt1decreases expressionISOSIRT1 (Homo sapiens)6480464CTDGlucose results in decreased expression of SIRT1 mRNA; Glucose results in decreased expression of SIRT1 proteinPMID:20068143 PMID:21778425 PMID:27049278 PMID:30431688 PMID:33957017
Sirt1decreases expressionISOSirt1 (Mus musculus)6480464CTDGlucose results in decreased expression of SIRT1 proteinPMID:20370652 PMID:23090186
Sirt1decreases response to substanceISOSirt1 (Mus musculus)6480464CTDSIRT1 protein results in decreased susceptibility to GlucosePMID:20370652
Sirt1increases expressionISOSIRT1 (Homo sapiens)6480464CTDGlucose deficiency results in increased expression of SIRT1 mRNA; Glucose deficiency results in increased expression of SIRT1 proteinPMID:20195491 PMID:24802182
Sirt1increases phosphorylationISOSIRT1 (Homo sapiens)6480464CTDGlucose deficiency results in increased phosphorylation of SIRT1 proteinPMID:26811028
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[Glucose co-treated with Resveratrol] results in increased expression of SIRT1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [ACACB protein affects the reaction [Glucose results in decreased expression of SIRT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [Resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]; [Glucose co-treated with Resveratrol] results in increased expression of SIRT1 protein; [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [Resveratrol results in increased expression of SIRT1 protein]; [Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]; [Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein; [Pyruvic Acid co-treated with Glucose] results in increased expression of and results in increased activity of SIRT1 protein; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides]; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]; ACACB protein affects the reaction [Glucose results in decreased expression of SIRT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein]; Glucose results in decreased expression of and results in decreased activity of SIRT1 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of SIRT1 protein]; PARP1 protein affects the reaction [Glucose results in decreased expression of SIRT1 protein]; PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]]; PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]]; PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]]; Resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 mRNA]; salvianolic acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; SIRT1 inhibits the reaction [Glucose results in increased expression of SHC1]; SIRT1 mutant form promotes the reaction [Glucose results in increased expression of SHC1 mRNA]; SIRT1 mutant form promotes the reaction [Glucose results in increased expression of SHC1 protein]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of NOS3 mRNA]]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of SELE mRNA]]; SIRT1 protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased acetylation of TP53 protein]; SIRT1 protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased cleavage of CASP3 protein]; SIRT1 protein inhibits the reaction [Glucose promotes the reaction [PARP1 protein binds to MMP9 promoter]]; SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]; SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]; SIRT1 protein inhibits the reaction [Glucose results in increased acetylation of PARP1 protein]; SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]; SIRT1 protein inhibits the reaction [Glucose results in increased expression of SHC1 mRNA]; SIRT1 protein inhibits the reaction [Glucose results in increased expression of SHC1 protein]; SIRT1 protein inhibits the reaction [Resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]; SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of BBC3 mRNA]; SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of CDKN1A mRNA]; SIRT1 protein promotes the reaction [[Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]]PMID:18482975 PMID:19071085 PMID:20068143 PMID:20960276 PMID:21031461 PMID:21163946 PMID:21778425 PMID:23993977 PMID:24064760 PMID:24451382 PMID:27049278 PMID:27358235 PMID:28478229 PMID:30431688 PMID:33957017
Sirt1multiple interactionsISOSirt1 (Mus musculus)6480464CTD[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased susceptibility to Glucose; [[Resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of BAD protein]; [Resveratrol results in increased localization of and results in increased activity of SIRT1 protein] which results in decreased susceptibility to Glucose; [SIRT1 protein co-treated with Resveratrol] affects the reaction [Glucose affects the expression of PPARGC1A protein]; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose; AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]; icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]; Metformin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; PRKAA1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]; PRKAA2 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]; Resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]]PMID:19303870 PMID:20370652 PMID:23090186
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