Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308374
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt3
Name: sirtuin 3
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt3decreases expressionISOSIRT3 (Homo sapiens)6480464CTDGlucose results in decreased expression of SIRT3 proteinPMID:37417536
Sirt3increases expressionISOSIRT3 (Homo sapiens)6480464CTDGlucose deficiency results in increased expression of SIRT3 proteinPMID:23494737
Sirt3multiple interactionsISOSIRT3 (Homo sapiens)6480464CTDpolyethylene glycol loxenatide inhibits the reaction [Glucose results in decreased expression of SIRT3 protein]; SIRT3 protein inhibits the reaction [Glucose results in increased acetylation of FOXO1 protein]; SIRT3 protein inhibits the reaction [Glucose results in increased expression of CAT protein]; SIRT3 protein inhibits the reaction [Glucose results in increased expression of CDKN2A protein alternative form]; SIRT3 protein inhibits the reaction [Glucose results in increased expression of GLB1 protein]; SIRT3 protein inhibits the reaction [Glucose results in increased expression of SOD2 protein]PMID:23494737 PMID:37417536
Sirt3multiple interactionsISOSirt3 (Mus musculus)6480464CTDSIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]PMID:25979314
Go Back to source page   Continue to Ontology report