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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69218 Species: Mus musculus RGD Object: Gene Symbol: Aldh2 Name: aldehyde dehydrogenase 2, mitochondrial

Acc ID: CHEBI:17153 Term: propanal Definition: An aldehyde that consists of ethane bearing a formyl substituent. The parent of the class of propanals. CasRN: 123-38-6 Chemical ID: MESH:C005556

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects metabolic processing	ISO	RGD:69220	6480464	CTD	ALDH2 protein polymorphism affects the metabolism of propionaldehyde	PMID:11744614
increases oxidation	ISO	RGD:69220	6480464	CTD	ALDH2 protein results in increased oxidation of propionaldehyde	PMID:21349255
multiple interactions	ISO	RGD:69220	6480464	CTD	daidzin inhibits the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]	PMID:21349255
increases metabolic processing	ISO	RGD:69220	6480464	CTD	ALDH2 protein results in increased metabolism of propionaldehyde	PMID:20954713
multiple interactions	ISO	RGD:69220	6480464	CTD	molinate sulfoxide inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde] molinate metabolite inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde] molinate inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]	PMID:20954713