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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61296
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aoc1
Name: amine oxidase, copper containing 1
Acc ID: CHEBI:17148
Term: putrescine
Definition: A four-carbon alkane-alpha,omega-diamine. It is obtained by the breakdown of amino acids and is responsible for the foul odour of putrefying flesh.
Chemical ID: MESH:D011700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aoc1increases metabolic processingEXP 6480464CTDAOC1 protein results in increased metabolism of PutrescinePMID:1644166
Aoc1increases degradationISOAOC1 (Homo sapiens)6480464CTDAOC1 protein results in increased degradation of PutrescinePMID:8144586
Aoc1increases metabolic processingISOAOC1 (Homo sapiens)6480464CTDAOC1 protein results in increased metabolism of PutrescinePMID:12072962
Aoc1multiple interactionsISOAOC1 (Homo sapiens)6480464CTDAmiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; ethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; phenylamil inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]PMID:8144586
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