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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1d1
Name: aldo-keto reductase family 1, member D1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1d1increases reductionISOAkr1d1 (Mus musculus)6480464CTDAKR1D1 protein alternative form results in increased reduction of Progesterone; AKR1D1 protein results in increased reduction of ProgesteronePMID:30928400
Akr1d1increases reductionISOAKR1D1 (Homo sapiens)6480464CTDAKR1D1 protein results in increased reduction of ProgesteronePMID:18624455
Akr1d1multiple interactionsISOAkr1d1 (Mus musculus)6480464CTD[AKR1D1 protein alternative form results in increased reduction of Progesterone] which results in increased chemical synthesis of 5-alpha-DihydroprogesteronePMID:30928400
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