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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3increases activityEXP 6480464CTDProgesterone results in increased activity of NOS3 proteinPMID:15358673
Nos3increases expressionEXP 6480464CTDProgesterone results in increased expression of NOS3 proteinPMID:15358673
Nos3decreases expressionISONOS3 (Homo sapiens)6480464CTDProgesterone results in decreased expression of NOS3 proteinPMID:21558462
Nos3increases activityISONOS3 (Homo sapiens)6480464CTDProgesterone results in increased activity of NOS3 proteinPMID:15358673
Nos3increases expressionISONOS3 (Homo sapiens)6480464CTDProgesterone results in increased expression of NOS3 mRNA; Progesterone results in increased expression of NOS3 proteinPMID:15358673 PMID:18710710
Nos3increases phosphorylationISONOS3 (Homo sapiens)6480464CTDProgesterone results in increased phosphorylation of NOS3 proteinPMID:15358673
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased activity of NOS3 protein]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; Mifepristone inhibits the reaction [Progesterone results in increased expression of and results in increased phosphorylation of NOS3 protein]; Mifepristone inhibits the reaction [Progesterone results in increased expression of NOS3 mRNA]; Mifepristone inhibits the reaction [Progesterone results in increased expression of NOS3 protein]; Org 31710 inhibits the reaction [Progesterone results in increased expression of NOS3 protein]; Org 31710 inhibits the reaction [Progesterone results in increased phosphorylation of NOS3 protein]; Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]; Progesterone results in increased expression of and results in increased phosphorylation of NOS3 protein; U 0126 inhibits the reaction [Progesterone results in increased phosphorylation of NOS3 protein]; Wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; Wortmannin inhibits the reaction [Progesterone results in increased activity of NOS3 protein]; Wortmannin inhibits the reaction [Progesterone results in increased phosphorylation of NOS3 protein]PMID:15358673 PMID:18710710
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