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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10919 Species: Mus musculus RGD Object: Gene Symbol: Abcc1 Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Acc ID: CHEBI:16978 Term: leukotriene C4 Definition: A leukotriene that has formula C30H47N3O9S. CasRN: 72025-60-6 Chemical ID: MESH:D017997

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects transport	ISO	RGD:1344624	6480464	CTD	ABCC1 protein affects the transport of Leukotriene C4	PMID:11278867
multiple interactions	ISO	RGD:1344624	6480464	CTD	Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]	PMID:15245331
multiple interactions	ISO	RGD:1344624	6480464	CTD	Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]	PMID:15459206 PMID:15355964
multiple interactions	ISO	RGD:1344624	6480464	CTD	Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]	PMID:15628876
affects binding	ISO	RGD:1344624	6480464	CTD	Leukotriene C4 analog binds to ABCC1 protein	PMID:15628876
multiple interactions	ISO	RGD:1344624	6480464	CTD	estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]	PMID:11278867
multiple interactions	ISO	RGD:1344624	6480464	CTD	Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]	PMID:15355964 PMID:15459206
multiple interactions	ISO	RGD:1344624	6480464	CTD	[Nimustine results in increased expression of ABCC1 protein] which results in increased transport of Leukotriene C4	PMID:9393752