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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2906 Species: Rattus norvegicus RGD Object: Gene Symbol: Cxcr2 Name: chemokine (C-X-C motif) receptor 2

Acc ID: CHEBI:168396 Term: mycophenolic acid Definition: A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases. CasRN: 24280-93-1 Chemical ID: MESH:D009173

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:735300	6480464	CTD	Mycophenolic Acid results in increased expression of CXCR2 mRNA	PMID:19818335