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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4increases expressionEXP 6480464CTDCorticosterone results in increased expression of CYP2D4 mRNAPMID:15755911
Cyp2d4increases expressionISOCYP2D6 (Homo sapiens)6480464CTDCorticosterone results in increased expression of CYP2D6 mRNAPMID:35301062
Cyp2d4multiple interactionsISOCYP2D6 (Homo sapiens)6480464CTDCorticosterone promotes the reaction [Ethanol results in increased expression of CYP2D6 mRNA]PMID:35301062
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