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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731580 Species: Mus musculus RGD Object: Gene Symbol: Hmgcr Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Acc ID: CHEBI:16755 Term: chenodeoxycholic acid Definition: A dihydroxy-5beta-cholanic acid that has formula C24H40O4. CasRN: 474-25-9 Chemical ID: MESH:D002635

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases response to substance	ISO	RGD:731579	6480464	CTD	HMGCR protein results in decreased susceptibility to Chenodeoxycholic Acid	PMID:7461467