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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10698
Species: Mus musculus
RGD Object: Gene
Symbol: Gstm2
Name: glutathione S-transferase, mu 2
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm2multiple interactionsISOGstm2 (Rattus norvegicus)6480464CTDChenodeoxycholic Acid binds to and results in decreased activity of GSTM2 proteinPMID:3954743
Gstm2multiple interactionsISOGSTM2 (Homo sapiens)6480464CTD[Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of GSTM2 mRNA; [nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of GSTM2 mRNAPMID:32152650
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