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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3651 Species: Rattus norvegicus RGD Object: Gene Symbol: Cxcl12 Name: chemokine (C-X-C motif) ligand 12

Acc ID: CHEBI:16716 Term: benzene Definition: A six-carbon aromatic compound in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system. CasRN: 71-43-2 Chemical ID: MESH:D001554

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:11280	6480464	CTD	Benzene results in increased expression of CXCL12 mRNA	PMID:15120971 PMID:15122651
increases expression	ISO	RGD:11280	6480464	CTD	Benzene results in increased expression of CXCL12 mRNA	PMID:15122651 PMID:15120971