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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:16643
Term: L-methionine
Definition: The L-enantiomer of methionine.
Chemical ID: MESH:D008715
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP1A2 mRNA; [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in decreased expression of CYP1A2 mRNA; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 mRNA; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 protein; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of CYP1A2 mRNAPMID:27712037 PMID:28163111 PMID:28973532 PMID:29127188
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