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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:16595
Term: 1D-myo-inositol 1,4,5-trisphosphate
Definition: A myo-inositol trisphosphate that has formula C6H15O15P3.
Chemical ID: MESH:D015544
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1increases abundanceEXP 6480464CTDEDN1 protein results in increased abundance of Inositol 1,4,5-TrisphosphatePMID:1443220
Edn1increases chemical synthesisEXP 6480464CTDEDN1 protein results in increased chemical synthesis of Inositol 1,4,5-TrisphosphatePMID:11911850
Edn1multiple interactionsEXP 6480464CTDcyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]PMID:11911850 PMID:1443220
Edn1increases chemical synthesisISOEDN1 (Homo sapiens)6480464CTDEDN1 protein results in increased chemical synthesis of Inositol 1,4,5-TrisphosphatePMID:20691780
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTDCAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]PMID:20691780
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