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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16509
Term: 1,4-benzoquinone
Definition: The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
Chemical ID: MESH:C004532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDquinone results in increased expression of HMOX1 proteinPMID:23290930 PMID:25437431
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDquinone results in increased expression of HMOX1 proteinPMID:21059386 PMID:28645578
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased expression of HMOX1 protein]; AG 1879 inhibits the reaction [quinone results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [quinone results in increased expression of HMOX1 protein]PMID:23290930
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDNFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]PMID:21059386
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