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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737579 Species: Mus musculus RGD Object: Gene Symbol: Slc11a2 Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	EXP		6480464	CTD	Estradiol affects the expression of SLC11A2 mRNA	PMID:16684588
multiple interactions	ISO	RGD:737578	6480464	CTD	Copper promotes the reaction [Estradiol results in increased expression of SLC11A2 mRNA] Estradiol inhibits the reaction [Copper results in decreased expression of SLC11A2 protein] Estradiol promotes the reaction [Copper affects the expression of SLC11A2 mRNA]	PMID:19685012
increases expression	ISO	RGD:737578	6480464	CTD	Estradiol results in increased expression of SLC11A2 mRNA	PMID:19685012