Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
| increases expression | ISO | RGD:1606587 | 6480464 | CTD | Estradiol results in increased expression of CYP19A1 mRNA
| PMID:16029874
|
| multiple interactions | EXP | | 6480464 | CTD | Estradiol affects the reaction [CYP19A1 affects the expression of BMP15 mRNA]
Estradiol affects the reaction [CYP19A1 affects the expression of IGF1 mRNA]
Estradiol affects the reaction [CYP19A1 affects the expression of IGF1R mRNA]
Estradiol affects the reaction [CYP19A1 affects the expression of GDF9 mRNA]
Estradiol affects the reaction [CYP19A1 affects the expression of PGR mRNA]
Estradiol affects the reaction [CYP19A1 affects the expression of VEGFA mRNA]
| PMID:11985600
|
| multiple interactions | ISO | RGD:2457 | 6480464 | CTD | [bisphenol A results in decreased expression of CYP19A1 mRNA] which affects the abundance of Estradiol
| PMID:18191889
|
| increases chemical synthesis | ISO | RGD:2457 | 6480464 | CTD | CYP19A1 protein results in increased chemical synthesis of Estradiol
| PMID:16569475
|
| affects activity | ISO | RGD:2457 | 6480464 | CTD | Estradiol affects the activity of CYP19A1 protein
| PMID:21068160
|
| decreases expression | ISO | RGD:2457 | 6480464 | CTD | Estradiol results in decreased expression of CYP19A1 mRNA
| PMID:18191889
|
| multiple interactions | ISO | RGD:2457 | 6480464 | CTD | [Testosterone results in increased expression of CYP19A1 protein] which results in increased abundance of Estradiol
[Testosterone results in increased expression of CYP19A1 mRNA] which results in increased abundance of Estradiol
| PMID:21273442
|
| multiple interactions | ISO | RGD:1606587 | 6480464 | CTD | 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Estradiol results in increased activity of CYP19A1 protein]
PD 98059 inhibits the reaction [Estradiol results in increased activity of CYP19A1 protein]
| PMID:12839940
|
| affects chemical synthesis | ISO | RGD:1606587 | 6480464 | CTD | CYP19A1 protein affects the chemical synthesis of Estradiol
| PMID:16030167
PMID:16024248
|
| increases chemical synthesis | ISO | RGD:1606587 | 6480464 | CTD | CYP19A1 protein results in increased chemical synthesis of Estradiol
| PMID:16054388
|
| affects expression | ISO | RGD:1606587 | 6480464 | CTD | Estradiol affects the expression of CYP19A1 mRNA
| PMID:14699072
|
| increases activity | ISO | RGD:1606587 | 6480464 | CTD | Estradiol results in increased activity of CYP19A1 protein
| PMID:15955695
PMID:12839940
|
| multiple interactions | ISO | RGD:1606587 | 6480464 | CTD | TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estradiol]
| PMID:16030167
|
| affects chemical synthesis | ISO | RGD:1606587 | 6480464 | CTD | CYP19A1 protein affects the chemical synthesis of Estradiol
| PMID:16024248
PMID:16030167
|
| increases activity | ISO | RGD:1606587 | 6480464 | CTD | Estradiol results in increased activity of CYP19A1 protein
| PMID:12839940
PMID:15955695
|
| multiple interactions | ISO | RGD:1606587 | 6480464 | CTD | [Atrazine results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol
[Forskolin results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol
| PMID:20087668
|
| multiple interactions | ISO | RGD:1606587 | 6480464 | CTD | [Water Pollutants, Chemical results in increased activity of CYP19A1 protein] which results in decreased metabolism of Estradiol
| PMID:20466405
|
| multiple interactions | ISO | RGD:1606587 | 6480464 | CTD | Estradiol promotes the reaction [ESR2 protein affects the expression of CYP19A1 mRNA]
| PMID:20404318
|
