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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731981
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNMA1
Name: potassium calcium-activated channel subfamily M alpha 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNMA1increases activityEXP 6480464CTDEstradiol results in increased activity of KCNMA1 proteinPMID:18068743
KCNMA1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of KCNMA1 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of KCNMA1 mRNA; iberiotoxin inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]; Progesterone inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]; Tetraethylammonium inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]PMID:18068743 PMID:20660070 PMID:30165855
KCNMA1decreases expressionISOKcnma1 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of KCNMA1 mRNA; Estradiol results in decreased expression of KCNMA1 mRNA alternative form; Estradiol results in decreased expression of KCNMA1 proteinPMID:16102753
KCNMA1multiple interactionsISOKcnma1 (Rattus norvegicus)6480464CTDfulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA alternative form]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 protein]PMID:16102753
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