RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	731438
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	MYC
Name:	v-myc myelocytomatosis viral oncogene homolog (avian)

Acc ID:	CHEBI:16469
Term:	17beta-estradiol
Definition:	The 17beta-isomer of estradiol.
CasRN:	50-28-2
Chemical ID:	MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:15833885 PMID:16155795 PMID:16093440
affects expression	EXP		6480464	CTD	Estradiol affects the expression of MYC mRNA	PMID:21826169
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:16474171 PMID:16839579 PMID:20106945 PMID:19244106 PMID:15072547 PMID:19584281 PMID:16051634 PMID:19838210 PMID:18997820 PMID:11896290 PMID:15833885 PMID:16093440 PMID:16155795 PMID:17266178 PMID:20945400 PMID:20049119 PMID:15528270 PMID:19654927
multiple interactions	EXP		6480464	CTD	fulvestrant inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:19654927
multiple interactions	EXP		6480464	CTD	methoxyacetic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:20049119
multiple interactions	EXP		6480464	CTD	4-fluorobenzoyl-TN-14003 inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:19584281
multiple interactions	EXP		6480464	CTD	4-hydroxy-N-desmethyltamoxifen inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:19244106
multiple interactions	EXP		6480464	CTD	BRCA1 protein affects the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:18997820
multiple interactions	EXP		6480464	CTD	benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]]	PMID:17157789
affects localization	EXP		6480464	CTD	Estradiol affects the localization of MYC protein	PMID:16327978
multiple interactions	EXP		6480464	CTD	Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]	PMID:19698761 PMID:17157789
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:20945400 PMID:17266178 PMID:15072547 PMID:16839579 PMID:15528270 PMID:18997820 PMID:19838210 PMID:11896290 PMID:19584281 PMID:19244106 PMID:16474171 PMID:20106945 PMID:16155795 PMID:16093440 PMID:15833885 PMID:16051634
multiple interactions	EXP		6480464	CTD	methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:16093440 PMID:16155795 PMID:15833885
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC protein	PMID:20204298 PMID:16327978 PMID:19647730
multiple interactions	EXP		6480464	CTD	SU 6656 inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:15528270
multiple interactions	EXP		6480464	CTD	Tamoxifen inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:16051634
multiple interactions	EXP		6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Estradiol] results in increased expression of MYC protein	PMID:16327978
multiple interactions	ISO	RGD:10940	6480464	CTD	AICDA protein affects the reaction [Estradiol results in increased mutagenesis of MYC gene]	PMID:19139166
increases mutagenesis	ISO	RGD:10940	6480464	CTD	Estradiol results in increased mutagenesis of MYC gene	PMID:19139166
multiple interactions	ISO	RGD:3130	6480464	CTD	Estradiol promotes the reaction [EGF protein results in increased expression of MYC mRNA]	PMID:12632255
multiple interactions	EXP		6480464	CTD	Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]	PMID:17157789 PMID:19698761
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC protein	PMID:20204298 PMID:19647730 PMID:16327978
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:16474171 PMID:19244106 PMID:17266178 PMID:11896290 PMID:20945400 PMID:16155795 PMID:16839579 PMID:15833885 PMID:16093440 PMID:19584281 PMID:15528270 PMID:18997820 PMID:15072547 PMID:20106945 PMID:19838210 PMID:16051634
multiple interactions	EXP		6480464	CTD	methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:16155795 PMID:16093440 PMID:15833885
increases expression	ISO	RGD:10940	6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:8390853
multiple interactions	ISO	RGD:10940	6480464	CTD	Progesterone promotes the reaction [Estradiol results in increased expression of MYC mRNA] Tetrahydrocannabinol inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:8390853
increases expression	ISO	RGD:3130	6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:2118345
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:20945400 PMID:19838210 PMID:15072547 PMID:16155795 PMID:19584281 PMID:16051634 PMID:16093440 PMID:20106945 PMID:15528270 PMID:17266178 PMID:19244106 PMID:15833885 PMID:19654927 PMID:16474171 PMID:18997820 PMID:20049119 PMID:16839579 PMID:11896290
multiple interactions	EXP		6480464	CTD	methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:16155795 PMID:15833885 PMID:16093440
multiple interactions	EXP		6480464	CTD	methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:15833885 PMID:16093440 PMID:16155795
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:18997820 PMID:16093440 PMID:20945400 PMID:20106945 PMID:19838210 PMID:15528270 PMID:16051634 PMID:15833885 PMID:15072547 PMID:17266178 PMID:11896290 PMID:16474171 PMID:16839579 PMID:20049119 PMID:19244106 PMID:19654927 PMID:16155795 PMID:19584281
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:19584281 PMID:15072547 PMID:20049119 PMID:16093440 PMID:19838210 PMID:19244106 PMID:18997820 PMID:16474171 PMID:16155795 PMID:19654927 PMID:15833885 PMID:16839579 PMID:20945400 PMID:17266178 PMID:16051634 PMID:11896290 PMID:20106945 PMID:15528270
multiple interactions	EXP		6480464	CTD	methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]	PMID:16093440 PMID:15833885 PMID:16155795
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:11896290 PMID:15072547 PMID:15528270 PMID:15833885 PMID:16051634 PMID:16093440 PMID:16155795 PMID:16474171 PMID:16839579 PMID:17266178 PMID:18997820 PMID:19244106 PMID:19584281 PMID:19654927 PMID:19838210 PMID:20049119 PMID:20106945 PMID:20945400
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC protein	PMID:16327978 PMID:19647730 PMID:20204298
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC mRNA	PMID:11896290 PMID:15072547 PMID:15528270 PMID:15833885 PMID:16051634 PMID:16093440 PMID:16155795 PMID:16474171 PMID:16839579 PMID:17266178 PMID:18997820 PMID:19244106 PMID:19584281 PMID:19654927 PMID:19838210 PMID:20049119 PMID:20106945 PMID:20945400 PMID:23019147
multiple interactions	EXP		6480464	CTD	[Estradiol binds to ESR2 protein] which results in decreased expression of MYC mRNA	PMID:20404318
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of MYC protein alternative form	PMID:15319301
multiple interactions	EXP		6480464	CTD	Estradiol promotes the reaction [MYC protein binds to DEK promoter]	PMID:23071688

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